(S)-Tert-butyl (piperidin-3-ylmethyl)carbamate

(S)-Tert-butyl (piperidin-3-ylmethyl)carbamate - Names and Identifiers

Name	(S)-3-N-Boc-Aminomethylpiperidine
Synonyms	(S)-3-N-Boc-Aminomethylpiperidine (S)-N-Boc-1-(3-piperidyl)methanamine S-3-N-Boc-Aminomethyl Piperidine Hydrochloride (S)-Tert-butyl (piperidin-3-ylmethyl)carbamate Carbamic acid, N-[(3S)-3-piperidinylmethyl]-, 1,1-dimethylethyl ester
CAS	1016167-99-9

(S)-Tert-butyl (piperidin-3-ylmethyl)carbamate - Physico-chemical Properties

Molecular Formula	C11H22N2O2
Molar Mass	214.3
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C

(S)-Tert-butyl (piperidin-3-ylmethyl)carbamate - Introduction

(S)-3-Boc-aminomethylpiperidine is an organic compound with the chemical name N-Boc-1-amino-1,2,3,4-tetrahydropyridine. The following is a description of its nature, use, preparation and safety information:

Nature:
(S)-3-Boc-aminomethylpiperidine is a solid with the appearance of white crystals or crystalline powder. Its molecular formula is C11H20N2O2 and its molecular weight is 216.29g/mol. It has good solubility and can be dissolved in some organic solvents such as dimethyl sulfoxide and dichloromethane.

Use:
(S)-3-Boc-aminomethylpiperidine is an important synthetic intermediate, which is widely used in the synthesis of drugs, pharmaceuticals and pesticides in organic synthesis. It can be used to synthesize a variety of biologically active compounds, including various cholinesterase inhibitors, analgesics, antidepressants, antibacterial agents, etc. In addition, it can also be used as a chiral inducer for the synthesis of chiral compounds.

Preparation Method:
The preparation of (S)-3-Boc-aminomethylpiperidine is generally obtained by reacting piperidine with (S)-Boc-α-aminopropionate. The reaction is carried out in a suitable solvent, and the reaction is allowed to proceed by heating and stirring. After completion of the reaction, the resulting product is purified by cooling crystallization, solvent distillation, and the like.

Safety Information:
(S)-3-Boc-aminomethylpiperidine is relatively safe under routine operation, but it is still necessary to follow laboratory safety procedures. Because it may cause irritation to the eyes, skin and respiratory tract, appropriate protective equipment such as gloves, glasses and breathing masks should be worn during operation. At the same time to ensure that the operating environment is well ventilated. Avoid contact with oxidants and strong acids during use and storage.

Last Update：2024-04-09 20:52:54